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Educational Articles

Cytomegalovirus Promotes Intestinal Inflammation by Blocking Anti-Inflammatory Signaling in Macrophages

NEW RESEARCH Cytomegalovirus (CMV) infection is prevalent worldwide, infecting an estimated 60% of the population in developed countries, and up to 100% of the population in developing countries.[1] Infection can occur at any age; in the US, up to 25% of children are infected by the age of five,... read more »

Common Gene Variant Predisposes to Irritable Bowel Syndrome

Implications for Precision Therapies   Overview The small intestinal brush border enzyme sucrase-isomaltase (SI) plays a critical role in carbohydrate digestion A common variant in the gene encoding SI was shown to be strongly associated with an increased risk of IBS  The SI gene variant was... read more »

Understanding Calprotectin and Lab-Specific Reference Ranges

by Heather Vatter, PhD What is Calprotectin? Calprotectin is a 36 kDa heterodimeric calcium bind protein that comprises approximately 60% of the cytosolic proteins present in inflammatory cells. Therefore, during intestinal inflammation, calprotectin quantification can be used to measure the... read more »

The GI-MAP™ in Clinical Practice

Last summer, two different boys, a ten-year-old and a seventeen-year-old, presented to my clinic with similar GI complaints. The families were unrelated and located in different areas, but both boys had symptoms of nausea, vomiting, and heartburn that were accompanied by poor reactions to certain... read more »

The Role Th17 and Treg Cells Play in the Gut and Autoimmunity

Recent research indicates that T helper 17 (Th17) and regulatory T (Treg) cells are critical contributors to mucosal and systemic immune responses, especially within the gut.  Imbalances in Th17 and Treg responses are thought to contribute to autoimmune processes and chronic inflammation, as... read more »

Altering the GI Microbiome with Exercise

As preventative health continues to be a primary focus, we continue to seek out ways to improve health through diet and lifestyle changes. At the same time, research continues to call our attention toward our gut and the microbes that reside within, as a primary influencer of our health.... read more »
GI-MAP Comprehensive Stool Test

Technology Update: Advances to the GI-MAP

Please Note: GI-MAP has been further enhanced since this post was published in 2018. Additional test information is available at: GI-MAP™ Enhanced with New Bacterial Biomarkers (2019) Additional test information is available at: The Industry's Leading Comprehensive Stool Test Just Got... read more »

Autoimmune Disease – What Lies Beneath

Autoimmune diseases have become increasingly more common. Medical doctors are taught that our health is the result of our genes, and that health is preprogrammed and predetermined. This view rejects the possibility that health reflects an accumulation of choices that we make and the environmental... read more »

Autoimmune Disease: A Modern Epidemic?

There is simply no doubt that the incidence of autoimmune disorders has been rising sharply over the past several decades in the Western industrialized countries, particularly the United States (See figure 1).1 A broad array of disorders considered immune-dysregulatory and autoimmune in nature,... read more »