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Educational Articles

GI Testing is Imperative, Even in Patients Without Digestive Complaints

GI Testing is Imperative, Even in Patients Without Digestive Complaints

Are You Assessing Gut Health First? If not, you could be missing the root cause of disorders. Practitioners often ask themselves, "Should I order a GI test on this patient, or not?" A few years ago, I traveled around the U.S. giving lectures on behalf of Diagnostic Solutions Laboratory, and at... read more »
The Arrival of Precision Medicine - A Genomics Approach

The Arrival of Precision Medicine

A Genomics Approach The Human Genome Project, completed in 2003, was a eureka-type of an event in modern medicine, and equally was a pivotal moment in the world of genomics. For the first time ever, we finally sequenced and mapped all of the genes of human beings. Immediately thereafter came the... read more »

Cytomegalovirus Promotes Intestinal Inflammation by Blocking Anti-Inflammatory Signaling in Macrophages

NEW RESEARCH Cytomegalovirus (CMV) infection is prevalent worldwide, infecting an estimated 60% of the population in developed countries, and up to 100% of the population in developing countries.[1] Infection can occur at any age; in the US, up to 25% of children are infected by the age of five,... read more »

Common Gene Variant Predisposes to Irritable Bowel Syndrome

Implications for Precision Therapies   Overview The small intestinal brush border enzyme sucrase-isomaltase (SI) plays a critical role in carbohydrate digestion A common variant in the gene encoding SI was shown to be strongly associated with an increased risk of IBS  The SI gene variant was... read more »

Understanding Calprotectin and Lab-Specific Reference Ranges

by Heather Vatter, PhD What is Calprotectin? Calprotectin is a 36 kDa heterodimeric calcium bind protein that comprises approximately 60% of the cytosolic proteins present in inflammatory cells. Therefore, during intestinal inflammation, calprotectin quantification can be used to measure the... read more »

The GI-MAP™ in Clinical Practice

Last summer, two different boys, a ten-year-old and a seventeen-year-old, presented to my clinic with similar GI complaints. The families were unrelated and located in different areas, but both boys had symptoms of nausea, vomiting, and heartburn that were accompanied by poor reactions to certain... read more »

The Role Th17 and Treg Cells Play in the Gut and Autoimmunity

Recent research indicates that T helper 17 (Th17) and regulatory T (Treg) cells are critical contributors to mucosal and systemic immune responses, especially within the gut.  Imbalances in Th17 and Treg responses are thought to contribute to autoimmune processes and chronic inflammation, as... read more »

Altering the GI Microbiome with Exercise

As preventative health continues to be a primary focus, we continue to seek out ways to improve health through diet and lifestyle changes. At the same time, research continues to call our attention toward our gut and the microbes that reside within, as a primary influencer of our health.... read more »
GI-MAP Comprehensive Stool Test

Technology Update: Advances to the GI-MAP

Please Note: GI-MAP has been further enhanced since this post was published in 2018. Additional test information is available at: GI-MAP™ Enhanced with New Bacterial Biomarkers (2019)   The Gastrointestinal Microbial Assay Plus (GI-MAP) is the first and only stool test in the... read more »