Histamine and the Microbiome: A Clinical Perspective Using GI-MAP
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Histamine-driven symptoms are common in clinical practice and frequently misunderstood. While dietary histamine avoidance may offer short-term relief, it rarely addresses the underlying drivers of reactivity or restores long-term tolerance.
In this clinician-led educational webinar, Dr. Amy Rolfsen explores histamine intolerance through a gut-centered, systems-based lens using GI‑MAP stool testing. The session focuses on how the gut environment — including microbial activity, digestion, immune signaling, and barrier function — shapes histamine production, clearance, and total histamine burden.
Drawing from clinical patterns and case-based reasoning, this webinar emphasizes mechanism and pattern recognition rather than protocol. This session is educational in nature and intended to support clinical reasoning and informed health conversations.
LEARNING OBJECTIVES:
By the end of this webinar, participants will be able to:
- Explain histamine physiology and why symptoms often appear multisystemic
- Understand how the gut microbiome and GI environment contributes to histamine burden
- Recognize why histamine reactions are often cumulative and variable
- Interpret common GI-MAP patterns associated with histamine-driven presentations
- Learn practical clinical pearls for approaching histamine reactivity
Amy Rolfsen, ND
Amy Rolfsen, ND, is a distinguished naturopathic physician, seasoned speaker, and dedicated medical educator renowned for her specialization in the intricate realm of the gut microbiome and gastrointestinal health.
In addition to her role at Diagnostic Solutions Laboratory, Dr. Rolfsen operates a thriving private practice, where she extends her services through virtual consultations specializing in lab interpretation, complex gastrointestinal conditions, and pediatric care.
The opinions expressed in this presentation are the author's own. Information is provided for informational purposes only and is not meant to be a substitute for personal advice provided by a doctor or other qualified health care professional. Patients should not use the information contained herein for diagnosing a health or fitness problem or disease. Patients should always consult with a doctor or other health care professional for medical advice or information about diagnosis and treatment.