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OMX | Organic Metabolomics

– An Advanced Organic Acids and Amino Acids Profile

Metabolomic Testing Offers Enhanced Insights into Patient Metabolic Status

The OMX ™ Organic Metabolomics test from Diagnostic Solutions Laboratory evaluates urine and plasma metabolites—including organic acids, amino acids, and other key compounds—to assist practitioners in unraveling their patient’s metabolic pathways, revealing their unique Metabolic Signature.

Using a systems-biology approach, OMX assesses biomarkers that go beyond the traditional lists of metabolites. This test enables practitioners to see a patient’s larger health picture by deciphering and connecting perturbations of key metabolic pathways and analytes, allowing for truly personalized therapeutic support.

 

Reveal Your Metabolic Signature

What is Metabolomics Testing?

Metabolomics, also called comprehensive metabolic profiling, evaluates patterns of metabolites related to core biological systems, offering insight into biochemical dysfunctions that may be of concern.

Organic acids and other small molecules are intermediate compounds that can define the efficient flow of pathways and substrates such as amino acids to reveal the level of inputs, which together establish the functional status of key areas of health.

Metabolites are impacted by many factors and can change in response to diet, nutrient status, toxin exposures, exercise, physiologic demands, genetics, gut microbiome alterations, or disease stage.

Metabolic analysis can help clinicians evaluate the function of key pathways to better target support.

 

 
“The metabolome is a measure of the inputs and outputs of biological pathways and, as such, is often considered more representative of the functional state of a cell than other 'omics measures such as genomics or proteomics.”
National Institutes of Health 1
 

Why Choose OMX Organic Metabolomics?

Identify Metabolomic Deviations

OMX™ metabolomic testing goes beyond traditional organic acid testing. OMX characterizes metabolic phenotypes by presenting analytes in pathway categories to more easily identify metabolomic deviations that can underlie—and even precede—disease.

OMX also offers additional key markers and ratios as a standard part of the profile, including cortisol, kynurenine, microalbumin, equol, and more.

OMX™ Testing Groups Urine and Plasma Analytes into Six Functionally Related Categories:

  • 1Metabolic Processing
  • 2Amino Acid & Protein Metabolism
  • 3Nutrition
Health Target Results Target

 
The front page of the OMX report provides an overview of impairment of each functional category that practitioners can use to easily review results with patients. This page includes useful charts, including a convenient "Health Target" graphic that can help patients immediately start to recognize their current metabolic signature.

The bulk of the multi-page report details every analyte detected, along with the enzymes that affect a patient's metabolic pathways. Customized treatment recommendations are also conveniently provided on the last page of the report. See the OMX Sample Report for more details.

Research-Based Insight to Optimize Patient Health

The OMX metabolomics test algorithms are based on published literature. Results offer actionable information practitioners can use to develop personalized interventions.
 


OMX Report Video Overview – [12:42]

 

What Patients Can Benefit from the OMX Metabolomics Test?

Understanding an individual's metabolome, combined with their medical history and lifestyle, allows clinicians to establish a larger picture and provide support from the bottom up. Ideally, practitioners will use OMX to establish a baseline metabolic signature for healthy patients. The baseline could be used for future comparison if symptoms, disease, or illness occurs.

 
Human Health Insight

OMX Provides Insight Into the Following Areas of Health:

  • Metabolic and macronutrient processing
  • Nutritional and vitamin status
  • Level and flow of amino acid
  • Detoxification
  • Mood issues
  • Gut concerns
  • Overall well-being
 

Patients

Are You a Patient?

A healthcare practitioner will need to order the test for you. That can be your own doctor, or you can contact us so we can help you find a practitioner in your area.

Optimizing Your Health

We know you want to be proactive about your health. OMX can help your doctor evaluate how you function to either optimize your current health or identify health issues that need attention.

At Diagnostic Solutions Laboratory, we believe in the practice of personalized medicine. Our goal is to help you achieve your health goals through research-based testing and treatment protocols tailored to your unique needs.

Doctor's Orders

Ask your practitioner about OMX, and how it can help you achieve better health!
 

 

How Can OMX Help to Translate Metabolomics Research into Clinical Care?

Metabolomics research has generally compared sick or disease populations to healthy controls, and identified the analytes, pathways, or categories that were most impacted. The research has concentrated on several conditions, including diabetes, autism, Alzheimer’s disease, obesity, fatty-liver disease, heart disease, toxic exposure, and more.

Emerging research is beginning to characterize core metabolic signatures and increase the understanding of biochemical relationships within different conditions or diseases. The OMX metabolomics test allows clinicians to identify markers or pathways that research has identified as most associated with specific disease or core impairments.

 
“…modern medicine will only be truly effective once it is has transitioned from reactive disease care to a framework that is predictive, preventive, personalized, and participatory.”
Leroy Hood 2
 

Combining Traditional Testing with Metabolomics

The New Framework of Healthcare

Current healthcare practices tend to be reactive and based on infrequent assessment of markers that diagnose frank disease. Characterizing an individual’s metabolomic, genomic, and microbiome status at baseline for comparison purposes over time will ideally become the new framework of healthcare.

As just one example, the benefits of incorporating metabolomics can be seen in the assessment of inborn errors of metabolism. For decades, traditional organic acids testing has been the standard for this screening, but it has limitations. Recent research identified that metabolomic profiling of inborn errors was found to have a six-fold higher diagnostic rate and can screen for significantly more metabolic diseases, when compared to traditional newborn screening.3*

 

Methodology

  • MS/MS – The newer testing results in significant increases in sensitivity & specificity, and increased reproducibility.

Specimen Requirements

  • Single first morning urine specimen and blood draw (patient must have fasted for the past eight [8] hours for blood draw)
  • Or single first morning urine specimen only
 
 
Order OMX - Organic Metabolomics

Test Ordering Options

There are two testing options for OMX™ | Organic Metabolomics:

  • OMX™ – Urine & Plasma (P)
  • OMX™ – Urine only
Order Now

If you already have an account with us, you may order through our online Results Portal accessible at the top of this page.


Optional Stand-Alone Profiles

Service Team

Complementary Panels for Complex Cases

  • GI-MAP – The GI-MAP was designed to detect microbes that may be disturbing normal microbial balance or contributing to illness as well as indicators of digestion, absorption, inflammation, and immune function.
  • GenomicInsight – Data gleaned from GenomicInsight informatics uses the latest medical literature to provide relevant information on nutraceuticals, nutritional supplements, diet, and lifestyle interventions that can proactively influence a patient's SNPs to reduce or prevent disease risk. Furthermore, pharmacogenomic results included in the profile allow practitioners to predict the efficacy of select pharmaceuticals tailored the individual's genetic make-up.

REFERENCES

  1. U.S. Department of Health and Human Services. (2016, March 9). Metabolomics Overview. National Institutes of Health. Retrieved November 23, 2021
  2. Hood, L. as cited in Miller, I.J., Peters, S.R., Overmyer, K.A. et al. Real-time health monitoring through urine metabolomics. npj Digit. Med. 2, 109 (2019).
  3. Beger RD, Dunn W, Schmidt MA, et al. Metabolomics enables precision medicine: "A White Paper, Community Perspective". Metabolomics. 2016;12(10):149.

* OMX™ | Organic Metabolomics testing is not intended for disease diagnosis. Information provided by Diagnostic Solutions Laboratory does not constitute medical advice; but is for educational purposes only. Services provided are for laboratory testing only. No charge is incurred for ordering collection kits.

 

Sample Report

OMX - Urine & Plasma

OMX - Organic Metabolomics Urine and Plasma Sample Report

OMX - Urine

OMX - Organic Metabolomics Urine Sample Report

View these multi-paged sample reports that feature a simple to understand overview of a patient's metabolic signature and health target results. Each analyte and enzyme pathway is also reported line-by-line, followed by personalized metabolic recommendations.


OMX Quick Reference Guide

OMX Quick Reference Guide

The OMX Quick Reference Guide provides a helpful snapshot of analytes tested, their role in patient health, and key metabolic pathways.


Product Brief

The OMX Product Brief includes a full list of analytes tested broken down by category and subcategory.