OAp - Organic Acids Profile
A Comprehensive Organic Acids Test for Functional Medicine
NEW! Additional Analytes. Enhanced Reporting. Greater Clinical Utility.
The updated OAp™ Organic Acids Profile is a comprehensive organic acids test designed to provide deeper insights into metabolism, gut health, mitochondrial function, and nutrient status.
Additional Analytes. Enhanced Reporting. Greater Clinical Utility.
The OAp Organic Acids Profile is a comprehensive organic acids test that now includes the following new markers and ratios for a more complete picture of overall functional health:
• Citramalic Acid (Fungal marker)
• Tricarballyic Acid (Fungal marker)
• Glyceric Acid (Oxalic Acid pathway)
• Glycolic Acid (Oxalic Acid pathway)
• Cortisol
• Albumen
• Glucose
• Homovanillic Acid (HVA) : Vanillymandelic Acid (VMA)
• Cortisol : Cortisone
• Quinolinic Acid (QA) : Kynurenic Acid (KA)
See the Clinical Info section below for update details.
With an expanded personalized summary page and algorithm-based nutraceutical recommendations, the OAp test highlights perturbations in metabolic pathways and nutrient deficiencies to help clinicians create actionable, individualized protocols for their patients. Whether assessing energy production, detoxification, or neurotransmitter balance, the OAp Organic Acids Profile enhances clinical decision-making and patient outcomes.
Documents
Explore our OAp - Organic Acids Profile educational resources. Learn about the markers on the test and how they impact overall health so you can better interpret results.
Clinical Information
Organic Acid Testing Offers Insights to Metabolic Pathways
The OAp™ organic acids test from Diagnostic Solutions Laboratory evaluates urine metabolites to identify the flow of biochemical pathways, revealing information about each person’s unique metabolic function.
Importance of Organic Acid Testing
Organic acids are intermediate compounds in metabolic pathways. The accumulation or reduction of specific organic acids can be due to many factors such as genetics, diet, nutrient status, toxin exposures, exercise, physiologic demands, gut microbiome, disease state, and others. Additionally, alterations in organic acid concentrations have been associated with a wide range of clinical conditions and symptoms.
Using a systems-biology approach, the OAp organic acids test enables practitioners to use these patterns of accumulation or reductions to identify each patient’s individual biochemical picture helping to create personalized recommendations.
The OAp Test Evaluates Several Areas, Including:
Energy & Mitochondrial Processing, which offers insight into:
- Glycolysis
- Krebs cycle (Mitochondrial function)
- Fatty acid oxidation
- Carnitine demand
- Ketones
Nutrition for information related to nutritional insufficiencies and:
- B-Complex (vitamin B1, B2, B3, B5 and lipoic acid), vitamin B12, B6, folate, and biotin
- Dietary intake: plant components and fructose intake
Stress & Mood for analysis of:
- Catecholamine turnover
- Serotonin turnover
- Neurological inflammation
- Cortisol and cortisone
Toxic Impacts for insight into the detoxification processes and assessment of:
- Oxidative damage
- Toxin exposure to xylene, styrene, and ethylbenzene
- Glutathione status
- Kidney function
- Oxalate metabolism
GI Microbial Metabolites for evaluation of gut dysbiosis through analytes related to:
- Tyrosine & tryptophan metabolites (protein fermentation)
- Polyphenol metabolites (saccharolytic fermentation)
- Glycine conjugation
- Equol production
- Fungal assessment
Who Can Benefit from the Organic Acids Profile?
The OAP - Organic Acids Profile helps practitioners identify metabolic dysfunctions that have been associated with a wide range of common clinical symptoms and conditions, including:
- Dysmetabolism, prediabetes, and diabetes
- Weight changes and obesity
- Fatigue
- Athletic performance
- Poor immune function
- Depression and anxiety
- GI symptoms
- Renal and liver dysfunction
Benefits of the OAp Organic Acid Test
- Non-Invasive: The Organic Acids Profile (OAp) is a urine-based test for easy administration and better patient compliance
- Early Detection: OAp can identify metabolic disturbances corresponding to clinical symptoms before traditional diagnostics, allowing for early intervention.
- Personalized Treatment Recommendations: Results can guide tailored dietary, nutritional, and lifestyle interventions, improving patient outcomes.
Personalized Reporting for Impactful Results
The OAp test report offers enhanced reporting that provides:
- A front summary page of functional imbalances that identifies markers outside the reference range, as well as highlighting borderline levels, calling attention to impacted nutrients and associated pathways.
- The final pages of the report provide personalized recommendations based on nutrients identified in the summary page and algorithm-derived recommendations. Recommendations are provided for vitamins, minerals, and additional support for inflammation, gastrointestinal (GI) issues, and targeted amino acids.
Test Methodology
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Analytical Technique: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of organic acids. This method offers high specificity and sensitivity.
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Results Presentation: Results are normalized to creatinine and listed as a percentile ranking within a quintile reference bar.
Specimen Requirements
- Sample Collection: Single first-morning urine sample is collected from the patient following standard protocols.
This test is not a standalone diagnostic tool but should be used in conjunction with other clinical evaluations and laboratory findings. Interpretation of the results should be performed by a qualified healthcare professional.
Test Ordering Options
- OAp™ - Organic Acids Profile – Urine
Optional Profiles
- OMX™ - Organic Metabolomix – Urine & Plasma
- AAp™ - Amino Acids Profile – Plasma
If you already have an account with us, you may order through our online Practitioner Portal accessible at the top of this page.
Complementary Panels for Complex Cases
- GI-MAP – The GI-MAP was designed to detect microbes that may be disturbing normal microbial balance or contributing to illness as well as indicators of digestion, absorption, inflammation, and immune function.
Order Organic Acids Profile
Organic acid testing provides insight into how well patients function metabolically. Practitioners can use insights from the Organic Acid Profile to personalize protocols to help patients improve dysfunctional pathways that may be contributing to current or future disease states.
Patient Information
Ask your practitioner about the Organic Acids Profile, and how it can help you achieve better health!
Are You a Patient? We're Here to Help
The Organic Acids Profile needs to be ordered by a practitioner. Your doctor can order the test for you, or we can help you find a functional medicine provider in your area.
Optimizing Your Health
We know you want to be proactive about your health. The Amino Acids Profile can help your doctor evaluate how you function to either optimize your current health or identify health issues that need attention.
We believe in empowering patients to achieve their health goals. Functional medicine testing, like the Organic Acids Profile, can help your doctor discover why you're not feeling well or help you maintain, or even improve, your current state of good health.
Diagnostic Solutions Laboratory is committed to providing the best functional medicine testing so that your doctor can provide precision-based protocols suited to your unique needs.
Please visit our Patient Billing Policies page for online answers to your questions. You may also reach us using one of the methods found on our Contact Us page.
Metabolomics, a 'budding' discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effects of epigenetic factors, such as nutrition, environment, drug and lifestyle on phenotype. Urine, being sterile, is easy to obtain and as it contains metabolized or non metabolized products, is a favored study material in the field of metabolomics. 2
REFERENCES
- Tsoukalas D; Alegakis A; Fragkiadaki P; Papakonstantinou E; Nikitovic D; Karataraki A; Nosyrev AE; Papadakis EG; Spandidos DA; Drakoulis N; Tsatsakis AM; (n.d.). Application of metabolomics: Focus on the quantification of organic acids in healthy adults. Int J Mol Med. Retrieved November 11, 2021.
- U.S. National Library of Medicine. (n.d.). Amino acids MedlinePlus. Retrieved November 11, 2021.
- Wu, G. (2018, April). Functional amino acids in nutrition and health. Amino Acids. Retrieved November 11, 2021.
- Clish, C. B. (2015, October). Metabolomics: An emerging but powerful tool for precision medicine. Cold Spring Harb Mol Case Stud. Retrieved November 11, 2021.
* Organic Acids Profile testing is not intended for disease diagnosis. Information provided by Diagnostic Solutions Laboratory does not constitute medical advice; but is for educational purposes only. Services provided are for laboratory testing only. No charge is incurred for ordering collection kits.